Cold Spring Harbor Laboratory researchers have reported that a bespoke antisense oligonucleotide can disrupt alternative ...

Genes contain the essential building instructions for life, guiding cells on which amino acids to assemble in what sequence to produce specific proteins. The human genome codes for about 20,000 such ...

In a new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A ...

Researchers uncovered how polyamines influence cell fate by altering protein phosphorylation and alternative splicing. The ...

The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which splicing ...

Genoa (Italy)/Grenoble (France) – 2nd July, 2024 - The correct functioning of cells relies heavily on the ability to finely control gene expression, a complex process by which the information ...

Alternative splicing is a process by which a cell can select which of those protein-coding parts to include in the resulting RNA or protein. Alternative splicing dysregulation is when this process ...

Trans-splicing is a unique process in gene expression where a short sequence, known as a spliced leader (SL), is added to the 5' end of mRNA molecules. This mechanism is particularly significant in ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger RNA—a prerequisite for protein synthesis in the cell. The poorly ...

In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists have recently identified the mechanism behind regulated splicing of large constitutive exons which ...