Regenerative medicines are headed for people with Parkinson’s disease or severe heart failure — but researchers are concerned about minimal clinical-trial data.

Resting brain stem cells hardly differ from normal astrocytes, which support the nerve cells in the brain. How can almost identical cells perform such different functions? The key lies in the ...

A pioneering clinical trial is exploring whether lab-engineered stem cells can restore dopamine production in people with Parkinson’s disease.

A mature cell of one type can be turned into a mature cell of another type without the cell having to pass through an earlier stage of development. This is called direct reprogramming, a reliable but ...

Researchers in Japan have developed a form of stem cell therapy that "reverses" paralysis. Though the treatment has only seen a 50% success rate so far, two of the four people who received it have ...

Parvalbumin (PV) interneurons act as the brain’s rhythm keepers. By regulating local circuit activity and maintaining excitation–inhibition balance, they help stabilize cortical network function. When ...

A groundbreaking clinical trial is testing whether specially engineered stem cells can help the brain restore its own ...

Pasca Lab specializes in growing three-dimensional organoid models from reprogrammed stem cells, which capture molecular changes during fetal brain-like development. Because the human brain cannot be ...

Life begins with a tiny orchestra of stem cells, setting the stage for the body’s grand symphony of development. As the performance unfolds, a dynamic interplay of factors takes center stage, ...