Prevalence and Spectrum of AR Ligand-Binding Domain Mutations Detected in Circulating-Tumor DNA Across Disease States in Men With Metastatic Castration-Resistant Prostate Cancer Six hundred and eight ...

The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving the way for personalized medicines. “We measured every possible mutation in ...

A new research paper was published in Volume 16 of Genes & Cancer on January 20, 2025, entitled, "Analysis of pathogenic variants in retinoblastoma reveals a potential gain of function mutation." ...

Germ cell tumors (GCTs) are a heterogeneous group of neoplasms that predominantly affect adolescents and young adults. Notably, geographical disparities in GCT incidence exist, with higher rates ...

Mutations in BRCA1 do not appear to contribute significantly to the risk of prostate cancer progression, according to DNA test results from 450 prostate cancer specimens. The findings suggest that ...

Breast-conserving therapy for BRCA1/2 mutation carriers has higher risks of future breast cancers than the general population, but most patients avoid another cancer event, and many remain bilateral ...

Universal genetic testing at an institution identified pathogenic germline variants in 14% of patients with genitourinary cancer. More than 1 in 8 patients with genitourinary malignancies in a recent ...

One mutation may have been crucial to the covid-19 variant JN.1 spreading rapidly around the world last year, demonstrating how quickly the virus can adapt. “A single mutation in JN.1 was key for it ...

"Reassuring" data show more breast cancers with surveillance, but no difference in surviva ...

One copy of the APOE3 Christchurch variant delayed onset of autosomal dominant Alzheimer's disease. Mild cognitive impairment occurred 5 years later than expected in people who had one copy of the ...