Nibbler (Nbr) is a 3′-to-5′ exoribonuclease whose catalytic 3′-end trimming activity impacts microRNA (miRNA) and PIWI-interacting RNA (piRNA) biogenesis. Here, we report on structural and functional ...

Potential of Field Is Catalyst for Emerging Diagnostic and Therapeutic Strategies As key regulators of gene expression and cellular machinery, microRNAs may be the most significant discovery in ...

The 2024 Nobel Prize in Physiology or Medicine was awarded to Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA and its pivotal role in post-transcriptional gene regulation.

Analyzing gene expression can provide a roadmap for deciphering the role of specific genes or elaborating critical players in functional metabolic pathways. Companies are pursuing solutions to better ...

The Nobel Prize in physiology or medicine was awarded Monday to Americans Victor Ambros and Gary Ruvkun for their discovery of microRNA, tiny pieces of genetic material that alter how genes work at ...

MicroRNAs are essential for Purkinje cells to develop their characteristically elaborate dendritic arbors. When Scripps Research scientists temporarily turned off microRNA function during development, ...

microRNAs (miRNA), non-coding RNA molecules, are widely known for regulating mRNA stability and translation. miR-10b has been increasingly implicated in the pathogenesis of gliomas, cancers of the ...

After years of type 2 diabetes, red blood cells may quietly turn against the heart—offering a new clue for spotting danger ...